Tissue tropisms opt for transmissible reassortants during avian and swine influenza A virus co-infection in swine
Identifieur interne : 000144 ( Main/Exploration ); précédent : 000143; suivant : 000145Tissue tropisms opt for transmissible reassortants during avian and swine influenza A virus co-infection in swine
Auteurs : Xiaojian Zhang [États-Unis] ; Hailiang Sun [États-Unis, République populaire de Chine] ; Fred L. Cunningham [États-Unis] ; Lei Li [États-Unis] ; Katie Hanson-Dorr [États-Unis] ; Matthew W. Hopken [États-Unis] ; Jim Cooley [États-Unis] ; Li-Ping Long [États-Unis] ; John A. Baroch [États-Unis] ; Tao Li [États-Unis] ; Brandon S. Schmit [États-Unis] ; Xiaoxu Lin [États-Unis] ; Alicia K. Olivier [États-Unis] ; Richard G. Jarman [États-Unis] ; Thomas J. Deliberto [États-Unis] ; Xiu-Feng Wan [États-Unis]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2018.
Abstract
Genetic reassortment between influenza A viruses (IAVs) facilitate emergence of pandemic strains, and swine are proposed as a “mixing vessel” for generating reassortants of avian and mammalian IAVs that could be of risk to mammals, including humans. However, how a transmissible reassortant emerges in swine are not well understood. Genomic analyses of 571 isolates recovered from nasal wash samples and respiratory tract tissues of a group of co-housed pigs (influenza-seronegative, avian H1N1 IAV–infected, and swine H3N2 IAV–infected pigs) identified 30 distinct genotypes of reassortants. Viruses recovered from lower respiratory tract tissues had the largest genomic diversity, and those recovered from turbinates and nasal wash fluids had the least. Reassortants from lower respiratory tracts had the largest variations in growth kinetics in respiratory tract epithelial cells, and the cold temperature in swine nasal cells seemed to select the type of reassortant viruses shed by the pigs. One reassortant in nasal wash samples was consistently identified in upper, middle, and lower respiratory tract tissues, and it was confirmed to be transmitted efficiently between pigs. Study findings suggest that, during mixed infections of avian and swine IAVs, genetic reassortments are likely to occur in the lower respiratory track, and tissue tropism is an important factor selecting for a transmissible reassortant.
Url:
DOI: 10.1371/journal.ppat.1007417
PubMed: 30507946
PubMed Central: 6292640
Affiliations:
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Cunningham</name><affiliation wicri:level="2"><nlm:aff id="aff003"><addr-line>Mississippi Field Station, National Wildlife Research Center, Wildlife Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Starkville, Mississippi State, Mississippi, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mississippi Field Station, National Wildlife Research Center, Wildlife Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Starkville, Mississippi State, Mississippi</wicri:regionArea><placeName><region type="state">État du Mississippi</region></placeName></affiliation></author><author><name sortKey="Li, Lei" sort="Li, Lei" uniqKey="Li L" first="Lei" last="Li">Lei Li</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi State, Mississippi, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi State, Mississippi</wicri:regionArea><placeName><region type="state">État du Mississippi</region></placeName></affiliation></author><author><name sortKey="Hanson Dorr, Katie" sort="Hanson Dorr, Katie" uniqKey="Hanson Dorr K" first="Katie" last="Hanson-Dorr">Katie Hanson-Dorr</name><affiliation wicri:level="2"><nlm:aff id="aff003"><addr-line>Mississippi Field Station, National Wildlife Research Center, Wildlife Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Starkville, Mississippi State, Mississippi, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mississippi Field Station, National Wildlife Research Center, Wildlife Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Starkville, Mississippi State, Mississippi</wicri:regionArea><placeName><region type="state">État du Mississippi</region></placeName></affiliation></author><author><name sortKey="Hopken, Matthew W" sort="Hopken, Matthew W" uniqKey="Hopken M" first="Matthew W." last="Hopken">Matthew W. Hopken</name><affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>National Wildlife Research Center, Wildlife Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Fort Collins, Colorado, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Wildlife Research Center, Wildlife Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Fort Collins, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff005"><addr-line>Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado State, Colorado, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado State, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Cooley, Jim" sort="Cooley, Jim" uniqKey="Cooley J" first="Jim" last="Cooley">Jim Cooley</name><affiliation wicri:level="2"><nlm:aff id="aff006"><addr-line>Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi State, Mississippi, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi State, Mississippi</wicri:regionArea><placeName><region type="state">État du Mississippi</region></placeName></affiliation></author><author><name sortKey="Long, Li Ping" sort="Long, Li Ping" uniqKey="Long L" first="Li-Ping" last="Long">Li-Ping Long</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi State, Mississippi, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi State, Mississippi</wicri:regionArea><placeName><region type="state">État du Mississippi</region></placeName></affiliation></author><author><name sortKey="Baroch, John A" sort="Baroch, John A" uniqKey="Baroch J" first="John A." last="Baroch">John A. Baroch</name><affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>National Wildlife Research Center, Wildlife Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Fort Collins, Colorado, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Wildlife Research Center, Wildlife Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Fort Collins, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Li, Tao" sort="Li, Tao" uniqKey="Li T" first="Tao" last="Li">Tao Li</name><affiliation wicri:level="2"><nlm:aff id="aff007"><addr-line>Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Schmit, Brandon S" sort="Schmit, Brandon S" uniqKey="Schmit B" first="Brandon S." last="Schmit">Brandon S. Schmit</name><affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>National Wildlife Research Center, Wildlife Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Fort Collins, Colorado, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Wildlife Research Center, Wildlife Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Fort Collins, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Lin, Xiaoxu" sort="Lin, Xiaoxu" uniqKey="Lin X" first="Xiaoxu" last="Lin">Xiaoxu Lin</name><affiliation wicri:level="2"><nlm:aff id="aff007"><addr-line>Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Olivier, Alicia K" sort="Olivier, Alicia K" uniqKey="Olivier A" first="Alicia K." last="Olivier">Alicia K. Olivier</name><affiliation wicri:level="2"><nlm:aff id="aff006"><addr-line>Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi State, Mississippi, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi State, Mississippi</wicri:regionArea><placeName><region type="state">État du Mississippi</region></placeName></affiliation></author><author><name sortKey="Jarman, Richard G" sort="Jarman, Richard G" uniqKey="Jarman R" first="Richard G." last="Jarman">Richard G. Jarman</name><affiliation wicri:level="2"><nlm:aff id="aff007"><addr-line>Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Deliberto, Thomas J" sort="Deliberto, Thomas J" uniqKey="Deliberto T" first="Thomas J." last="Deliberto">Thomas J. Deliberto</name><affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>National Wildlife Research Center, Wildlife Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Fort Collins, Colorado, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Wildlife Research Center, Wildlife Services, Animal and Plant Health Inspection Service, United States Department of Agriculture, Fort Collins, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Wan, Xiu Feng" sort="Wan, Xiu Feng" uniqKey="Wan X" first="Xiu-Feng" last="Wan">Xiu-Feng Wan</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi State, Mississippi, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi State, Mississippi</wicri:regionArea><placeName><region type="state">État du Mississippi</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Pathogens</title><idno type="ISSN">1553-7366</idno><idno type="eISSN">1553-7374</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Genetic reassortment between influenza A viruses (IAVs) facilitate emergence of pandemic strains, and swine are proposed as a “mixing vessel” for generating reassortants of avian and mammalian IAVs that could be of risk to mammals, including humans. However, how a transmissible reassortant emerges in swine are not well understood. Genomic analyses of 571 isolates recovered from nasal wash samples and respiratory tract tissues of a group of co-housed pigs (influenza-seronegative, avian H1N1 IAV–infected, and swine H3N2 IAV–infected pigs) identified 30 distinct genotypes of reassortants. Viruses recovered from lower respiratory tract tissues had the largest genomic diversity, and those recovered from turbinates and nasal wash fluids had the least. Reassortants from lower respiratory tracts had the largest variations in growth kinetics in respiratory tract epithelial cells, and the cold temperature in swine nasal cells seemed to select the type of reassortant viruses shed by the pigs. One reassortant in nasal wash samples was consistently identified in upper, middle, and lower respiratory tract tissues, and it was confirmed to be transmitted efficiently between pigs. Study findings suggest that, during mixed infections of avian and swine IAVs, genetic reassortments are likely to occur in the lower respiratory track, and tissue tropism is an important factor selecting for a transmissible reassortant.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Rivailler, P" uniqKey="Rivailler P">P Rivailler</name></author><author><name sortKey="Conrardy, C" uniqKey="Conrardy C">C Conrardy</name></author><author><name sortKey="Castillo, Da" uniqKey="Castillo D">DA Castillo</name></author><author><name sortKey="Chen, Lm" uniqKey="Chen L">LM Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name></author><author><name sortKey="Zhu, X" uniqKey="Zhu X">X Zhu</name></author><author><name sortKey="Li, Y" 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du Mississippi"><name sortKey="Zhang, Xiaojian" sort="Zhang, Xiaojian" uniqKey="Zhang X" first="Xiaojian" last="Zhang">Xiaojian Zhang</name></region><name sortKey="Baroch, John A" sort="Baroch, John A" uniqKey="Baroch J" first="John A." last="Baroch">John A. 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Jarman</name><name sortKey="Li, Lei" sort="Li, Lei" uniqKey="Li L" first="Lei" last="Li">Lei Li</name><name sortKey="Li, Tao" sort="Li, Tao" uniqKey="Li T" first="Tao" last="Li">Tao Li</name><name sortKey="Lin, Xiaoxu" sort="Lin, Xiaoxu" uniqKey="Lin X" first="Xiaoxu" last="Lin">Xiaoxu Lin</name><name sortKey="Long, Li Ping" sort="Long, Li Ping" uniqKey="Long L" first="Li-Ping" last="Long">Li-Ping Long</name><name sortKey="Olivier, Alicia K" sort="Olivier, Alicia K" uniqKey="Olivier A" first="Alicia K." last="Olivier">Alicia K. Olivier</name><name sortKey="Schmit, Brandon S" sort="Schmit, Brandon S" uniqKey="Schmit B" first="Brandon S." last="Schmit">Brandon S. Schmit</name><name sortKey="Sun, Hailiang" sort="Sun, Hailiang" uniqKey="Sun H" first="Hailiang" last="Sun">Hailiang Sun</name><name sortKey="Wan, Xiu Feng" sort="Wan, Xiu Feng" uniqKey="Wan X" first="Xiu-Feng" last="Wan">Xiu-Feng Wan</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Sun, Hailiang" sort="Sun, Hailiang" uniqKey="Sun H" first="Hailiang" last="Sun">Hailiang Sun</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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